Progressive multifocal leukoencephalopathy with selective involvement of the pyramidal tracts
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Progressive multifocal leukoencephalopathy with selective involvement of the pyramidal tracts.
A 67-year-old man with chronic lymphatic leukemia presented with a 1-month history of subacute right hemiparesis with right central facial palsy and right extensor plantar response, but without sensory deficits. MRI showed hyperintense lesions along the pyramidal tracts on T2-weighted and FLAIR images (figure). CSF PCR revealed JC virus infection leading to the diagnosis multifocal leukoencepha...
متن کاملUnusual MR Feature Presenting Discrete Involvement of Pyramidal Tract in Progressive Multifocal Leukoencephalopathy: A Case Report
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by reactivation of JC virus in immunocompromised patients. To date, PML with discrete involvement of the pyramidal tract has been described in only two patients. This report describes an additional case with PML showing discrete involvement of the pyramidal tract on T2-weighted images and FLAIR images.
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Progressive multifocal leukoencephalopathy (PML) is a rare, myelin-damaging disease of the central nervous system (CNS) in a setting of immunosuppression that is superimposed by concurrent autoimmune diseases such as multiple sclerosis and AIDS or simultaneous administration of immune modulatory monoclonal antibody drugs such as natalizumab. The causative agent is a Polyomavirus known as John C...
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ژورنال
عنوان ژورنال: Neurology
سال: 2007
ISSN: 0028-3878,1526-632X
DOI: 10.1212/01.wnl.0000257132.24299.76